柳州市大规模人群甲型肝炎减毒活疫苗流行病学效果考核

A Prospetive Epidemiological Investigation on the Effect of China-mode Attenuated Live Vac-cine Against Hepatitis A in the Population of Liu Zhou

应用国产甲型肝炎（下称甲肝）减毒活疫苗采用整群随机分组方法进行流行病学效果考核，经一年半时间观察，疫苗组发病率为１５．９１／１０万（５／３１４２１），对照组为９５．９２／１０万（３０／３１２７７）；而接种组中拒（漏）种的２０８１人中，发病１例，发病率为４８．０５／１０万，对照组误种７６０人中则无病例发生。外对照的７１４４６１人中，发病６４４例，发病率为９０．１４／１０万。外对照人群、对照组、接种组拒（漏）种人群发病率无明显差异。接种组发病率与以上三组人群发病率比较，保护率分别为８２．３５％、８３．４１％和６６．８９％，而与对照组的误种人群比较则无明显差别。

iu Zhou Cygine and Epidemic Prevention Station An 24-month prospective epidemiological investigation on the results of China-mode HepatitisA attenuated live vaccine againist hepatitis A by random group sampling was carried out. The inci-dence of case group was 15.91/10￣ 5(5/31421),the incidence of control group was 95. 92/10￣5 (30/31277)which showed a signifecant difference. In case group 2081 persons who missed vaccination,there was one preson developed hepatitis A, making the incidence 48.05/10￣5. In control group 760persons were vaccinated by mistake and there was no case developed in this sub-population. Therewere 644 cases of hepatitis A in the external control group, the incidence was 90. 14/10￣5.Datashowed that there was no significant difference among external control group,control group andpersons from case group who missed vaccination. Comparing the data from case group and from theabove 3 groups,the protective rates were 82.35%,83.41%、and 66. 89%. respectively.When con-paring the data from persons who had been mistakenly vaccinated in control group,there was nosignifecant difference being noticed.