摘要
笔者对１４３名４～７月龄婴儿麻疹胎传抗体及其对麻疹疫苗的免疫应答情况进行了研究，结果表明：４～７月龄婴儿麻疹胎传抗体的阴性率为７５．００％～９４．８７％，且６～７月龄婴儿较４～５月龄婴儿的阴性率更低（χ￣２＝５．１１，Ｐ＜０．０５）；而４～７月龄婴儿初免麻疹疫苗后，其免疫成功率为８４．３８％～１００．００％，６～７月龄婴儿的免疫成功率显著高于４～５月龄的婴儿（χ￣２＝５．３７，Ｐ＜０．０５），ＧＭＴ在各月龄组婴儿中的差异亦存在显著性意义（Ｆ＝５．４０，ｄｆ＝３，ｐ＜０．０１）。另外，初免麻疹疫苗前麻疹抗体的滴度对免疫应答结果有明显的影响。综合以上结果，笔者认为要减少１岁内婴儿（尤其是９月龄以下婴儿）麻疹的发病，应将麻疹疫苗的初免时间提前至６月龄。
A total number of 143 infants at the age of 4 to 7
months from Yantai city-Shandong was se-lected for the study of
antibody level against measles by maternal-fetal transfer and
immuno-res-ponse to measles vaccine in October of 1993.The results
showed that the negative rates of mater-nal-fetal antibody among
infants of 4,5,6 and 7 month olds were 75.00%, 81.25%, 94.87% and 90.
91%,respectively.The positive rates and geometric mean titers(GMTs)
for immuno-re-sponse to measles vaccine were 92.86%, 84.38%,
97.44%,100.00%and 55.17,42.41,69.95,71.46, respectively, There was
significant lower immune response to measles vaccine in infants who
had high titer(>1:2)than those who had low titer(<1:2) of
maternal-fetal antibody(χ￣2 =88.38,P<0.001).In order to decrease
the number of measles cases under 1 year old(especially under 9
month-old),the author suggested that the primary immunization for
measles vaccine should be started at 6 month olds.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
1995年第5期263-265,共3页
Chinese Journal of Epidemiology
