河南省人群丁型肝炎病毒感染的血清流行病学调查研究

A Seroepidemiological Study on Hepatitis D Virus(HDV)Infection ih Henan Province,China.

为了了解河南省丁型肝炎病毒（ＨＤＶ）的人群感染情况，从１９９１～１９９３年对河南省十三个地区１１８２例ＨＢｓＡｇ阳性的各型乙肝病人及无症状ＨＢｓＡｇ携带者血清标本进行ＨＤＡｇ、抗－ＨＤＶ和ＩｇＭ－抗－ＨＤＶ三项标志检测。结果表明，河南省人群ＨＤＡｇ、抗－ＨＤＶ、ＩｇＭ－抗－ＨＤＶ的总感染率分别为３．０％、３．５％、３．５％、８．１％。由此可见，河南地区确实存在有ＨＤＶ感染，各地区感染率略有差别。从ＨＤＶ感染率的年龄和性别分布来看，女性组（１０．１％）略高于男性组（７．３％），６０岁以上年龄组（２１．４％）高于其它各年龄组。通过对各型乙肝病人血清标本中的ＨＤＶ标志检测发现，携带者、急性乙肝、慢活肝、慢迁肝、肝硬化、重肝组病人ＨＤＶ总感染率依次为８．７％、１．６％、７．７％、６．３％、１１．９％、０．０％，其中以肝硬化组病人ＨＤＶ感染率最高。本研究结果证明ＨＤＶ和ＨＢＶ确实存在有重叠和重复感染，ＨＤＶ的感染对ＨＢＶ感染的慢性化和肝硬化的形成起一定的促进作用，在临床上应引起足够重视。

n order to investigate the distribution of HDV infection in Henan province,a seroepidemio-logical study on HDV infection was conducted.A total number of 1182 HBsAg positive serum sam-ples was collected from 13 prefectures and cities between 1991 and 1993.HDV markers (HDAg,anti-HDV,anti-HDV-IgM)were tested with Enzyme Linked Immunosorbant Assay(ELISA).Theprevalence rates of HDAg,anti-HDV,anti-HDV-IgM and HDV infection rate were 3.0%,3.5%,3.5%and 8.1%,respectively.There were no statistically significant differences in the prevalencerates of HDV infection in patients of different sexes but significant differences in the prevalencerates of HDV infection in patients of different ages,especially in age group above 60,were noticed.We also noticed that the infection rates of HDV were 8.7%,4.6%,7.7%,6.3%,11.9%and0.0%in the groups of HBsAg carriers, acute hepatitis,chronic active hepatitis,chronic persistenthepatitis, liver cirrhosis and severe hepatitis,respectively.These findings indicated that HDV infec-tion was important in the pathogenesis of chronic hepatitis B and in the exacerbation from liver dis-ease to cirrhosis.