胰高血糖素在家兔脊髓水平的升压与抗休克作用的实验研究

The experimental study of the pressor and antishock effects of glucagon in the spinal cord of the rabbit.

采用记录家兔颈总动脉血压与一侧肾交感神经传出放电的方法，研究脊髓蛛网膜下腔注射胰高血糖素对心血管活动的影响。结果显示，鞘内注射胰高血糖素（４０μｇ／４０ｕｌ）可明显提高肾交感神经传出放电，加强心血管的活动，提高家兔动脉血压；摘除双侧肾上腺后，则明显降低胰高血糖素的中枢升压效应；等量胰高血糖素静脉注射，动脉血压轻度降低或无明显影响。颈1 （Ｃ1 ）横断脊髓的脊髓休克与失血性休克家兔，鞘内注射胰高血糖素亦具有显著的增加肾交感神经放电与提高动脉血压的作用。本实验结果提示，胰高血糖素作为一种新的中枢交感神经兴奋药在临床麻醉与医疗中可能具有较重要的作用。

To evaluate the consequence of glucagon at the level of spinal cord on sympathetic responses,the effects of glucagon given intrathecally on renal sympathetic electrical activity and the mean arterial bood pressure were observed in sixteen rabbits. The results showed that intrathecally administered glucagon (40ug/40ul) significantly moresed the renal sympathetic efferent discharges,immediately following which the mean arterial blood pressure was markedly elevated (P< 0. 05 ), however a equivalent dose of glucagon (40ug/40ul) injected intravenously had no (obvious pressor effect. by contraries,a larger dose of glucagon (40ug) IV dramatically decreased the mean arterial blood pressure (P<0. 05 );after the extirpation of bilateral adrenals , the pressor effect of intrathecal glucagon was obviously reduced (P<0. 05 );in the spinal shock and hemorrhagic shock rabbits,intrathecal glucagon stimulated the sympathetic-adrenal medulla system and promoted the recovery of the mean arterial blood pressure. These results suggest that glucagon may be applied as a central sympathetic stimulant to elevating blood pressure in clinical anesthesia.