川芎嗪对大鼠在体缺氧性肺血管收缩反应的影响

Effects of ligustrazine on hypoxic pulmonary vasoconstriction: an experimental study in vivo.

以大鼠在体（ｉｎ ｖｉｖｏ）全血恒流灌注模型观察川穹嗪对缺氧性肺血管收缩（ＨＰＶ）反应的影响。血液恒流灌入肺动脉的速度为１４ｍｌ／ｍｉｎ，平均肺动脉压（ＭＰＡＰ）为２．４４±０．４２ｋＰａ，吸入３％Ｏ２＋４％ＣＯ２＋９３％Ｎ２混合气后，ＭＰＡＰ明显升高至３．６９±０．５５ｈＰａ，产生ＨＰＶ反应。当注入川芎嗪４ｍｇ／ｋｇ和 ８ｍｇ／ｋｇ后， ＭＰＡＰ分别下降至 ２． ９０± ０． ３０ｋＰａ和 ２． ４８± ０． ３３ｋＰａ，抑制升压反应分别为 ６３％和９６％。结果表明，川芎嗪可明显抑制ＨＰＶ且与剂量有关。

To investigate the effects of ligustrazine (LT) on hypoxic pulmonary vasoconstriction (HPV) in vivo,the lungs of nine male rates served as the experimental subjects. The status of pulmonary vasoconstriction was indicated by the levels of the perfused pressure (PP), under which the pulmonary blood flow was pumped at a constant rate. With the perfused lungs being ventilated with a mixture of 3 % oxygen, 4 % carbon dioxide and 93 % nitrogen, the level of PP increased from 2. 44 0. 24 to 3. 69 0. 54kpa,indicating that HPV was developed. Afterwards,LT at a dose of 4mg. kg-1 was administrated to the perfused pulmonary blood,and two hours later when PP returned to the primary high level, LT at a dose of 8mg. kg-1 was given subseqently. The PP was recorded continuously with a pressure monitor during the entire procedures. The results revealed that following the administration of LT 4mg. kg-1 or 8mg. kg-1,the level of PP decreased by 63% or 96% respectively. It is concluded that LT can inhibit HPV effectively,and the degree of the effect may be releted to the dosage.