1,6-二磷酸果糖对犬内毒素休克血流动力学的影响

Effects of fructosc 1, 6--diphosphate on the hemodynamic changes in canine endotoxin shock.

１２只犬随机分为两组：内毒素休克组（ＥＴ），内毒素休克治疗组（ＦＤＰ组）。麻醉后机械通气，分别插入动脉导管及 Ｓｗａｎ－Ｇａｎｚ漂浮导管并联接于 ＢＳＭ－８３０１Ｊ／Ｋ生理记录仪。外周静脉注射灭活大肠杆菌（２．７×１０１２／ｋｇ）。３０、９０分钟后ＦＤＰ经外周静脉输入３７５ｍｇ／ｋｇ。ＥＴ组输入等容量平衡盐液。注射ＥＴ前、后１至８小时测血流动力学及心功能指标。结果。注射ＥＴ前两组各项指标间无明显差异，注射后ＣＩ、ＭＡＰ、ＰＡＭＰ、ＰＣＷＰ、ＳＶＩ、ＬＳＷＩ明显低于注射前，且ＥＴ组呈进行性下降，而ＦＤＰ组则逐渐回升至正常水平。８小时死亡率ＦＤＰ组明显低于ＥＴ组。这说明ＦＤＰ通过改善心功能、恢复血流动力学对ＥＴ休克有较好疗效，能显著延长ＥＴ休克犬存活时间。

The effects of fructose 1, 6-diphosphate (FDP)on the hemodynamic variations in twelve dogs with endotoxin shock were observed. Following anesthesia,arterial and Swan-Gang catheters were inserted correspondingly into femoral and pulmonary arteries At 30mins and 90 mins following intravenous injection of endotoxin(IIE),these subjects were randomly assigned to receiving intravenous infusion of FDP at a dosage of 375mg/kg(group I,n= 6) or the equivalent volume of saline as control(group ,n= 6) The hemodynamic parameters of both groups were measured before IIE and every hour during 8 hours after IIE respectively. The results demonstrated that before IIE,there were not significant differences in the values of all parameters between both groups;im- mediately followillg IIE, the values of CI, MAP, PAMP, PCWP, SVI, LSWI, RSWI markedly decreased in both groups (P<0. 01 ). subsequently continued to reduce in group (P<0. 01 ), however, were increasingly ascended to and maintained at the normal levels in group (P<0.01 ). As compared with the controlled levels in group ,the above values of hemodynamic parameters following the administration of FDP increased dramatically (P<0. 05) and the mortality was greatly depressed in group I (P< 0. 05 ). It is coneluded that FDP may be helpful to improve The hemodynamics during endotoxin shock.