摘要
用选择性α1肾上腺素能受体阻滞剂盐酸四喃唑嗪(商品名高特灵)治疗有症状BPH患者,并用非选择性a受体阻滞剂酚苄明和安慰剂作对照治疗。30例患者随机分为三组,每组10例,实验组用高特灵4mg/d,对比治疗组用酚苄明20mg/d,对照组用安慰剂2片/d,均3周为一个疗程。结果表明:两种药物均能明显改善排尿困难等主观症状,显著增加尿流率(P<0.05),非常显著降低前列腺压(P<0.01),但对于降低膀胱颈压,高特灵优于酚苄明。与酚苄明相比较,高特灵的用药量少、副作用小而轻,对照组服药前后症状及尿动力学检查无显著变化。
patients with symptomatic benign prostatic hyperplasia (BPH) were treated with terazosin (a selective-adrenoceptor blocker) or Zhu Lin An (a non-selective-adrenoceptor blocker). Terazosin (1 ̄4mg/d )was instituted in 10 and Zhu Lin An (20 mg/d) in another 10 for a course of 3 weeks. Improvement in subjective symptoms and objective urodynamic changes were observed. The results demonstrated that both Terazosin and Zhu Lin An could significantly improve the subjective symptoms, decrease the prostatic pressure(P<0.05) and increase the urinary flow rates (P <0.01). Terazosin (P<0.01) was however better than Zhu Lin An ( P<0.05) in decreasing the pressure at bladder neck and with less adverse side effects. So Terazosin is safe and effective in the treatment of benign prostatic hyperplasia.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1995年第1期24-26,共3页
Chinese Journal of Urology