监测肾移植术后IL－2和sIL－2R的变化及其意义

Sequential determination of IL-2 and sIL-2R in renal transplant recipients

对７２例肾移植患者术后血清ＩＬ－２和ｓＩＬ－２Ｒ进行检测，分析移植术后ＩＬ－２和ｓＩＬ－２Ｒ的变化规律，发现在急性排斥和继发感染时，患者血中ＩＬ－２和ｓＩＬ－２Ｒ含量均明显升高．认为监测肾移植术后ＩＬ－２和ｓＩＬ－２Ｒ的变化有助于了解免疫抑制水平和体内免疫系统的功能状态，并可早期诊断急性排斥和继发感染．

Serum IL-2 and sIL-2R levels were determined in 72 renal allograft recipients. Both the IL-2 and sIL-2R dropped immediately after transplantation and tended to rise at the 7th-8th posttransplantation week. Serum IL-2 and sIL-2R elevated significantly during acute rejection(29.63±6.34U/ml and 885.90±252. 26 U/ml,respectively)and infection(21.98±5.47 U/ml and 818. 89±268.18 U/ml, respectively)and their monitoring following renal transplantation would be helpful to the assessment of acute rejection and infection.