ALG和AHTG在肾移植术后急性肾功能衰竭中的应用

The prophylactic use of ALG/AHTG in acute renal failure after renal transplantation

对１４例肾移植术后４８小时内出现肾功能衰竭的患者应用猪抗人胸腺细胞球蛋白（ＡＨＴＧ）和进口马抗人胸腺淋巴细胞球蛋白（ＡＬＧ），结果发现７１．４％患者肾功能恢复，同期对照组仅４４．４％；一年内４０．０％患者出现排斥反应，而对照组为６２．５％；一年内排斥次数，肾功能恢复时间和进程等则与对照组无明显差异．肾移植术后早期肾功能衰竭的最常见原因为排斥因素，其次为急性肾小管坏死以及手术并发症．

A retrospective comparison of the prophylactic use of ALG/AHTG vs.methylprednisolone(MP)was evaluated in patients who had acute renal faiure after a cadaveric renal transplantation. 10 patients(71.4%)and 8 patients (44.4%)were successfully reversed in ALG/AHTG and MP group respectively.The incidence rate of rejection episodes was 40% in ALG/AHTG and 62.5% in MP group.The most common cause of acute renal faiure after renal transplantation was acute or accelerated rejection respectively.ATN or surgical complications might be the others.