有关制动综合征尿石形成危险因素及其防治

An investigation of the risk factors and the prevention of urinary stone formation in immobilized patients

对２７例非泌尿系感染卧床早期（前４周）病人进行了观察和研究：１５例患者的尿钙、尿磷、尿尿酸均明显高于健康人，成石相对概率值分别增加０．４０、０．３７、０．３５及０．２９，（Ｐｓｆ）均超过正常值上限；１２例患者服用双氢克尿噻（ＤＨＣＴ）后，２４小时尿钙于第２～４周分别下降０．２４、０．３９及０．３５，第４周Ｐｓｆ值均降至正常范围。结果认为：卧床制动可增加泌尿系结石形成的危险性，ＤＨＣＴ是防治卧床病人尿石形成的有效措施之一。

Risk factors of urinary stone formation in the first 4 weeks of confinement were investigated in 15 male immobilized patients.The results revealed that Uca,UP and Uua were significantly elevated and the Psf(possibility of stone formation) values during the entire 4-week period increased 0.4,0.37,0.35 and 0.29 respectively,the mean Psf values being above the upper limit of normal range.For 12 patients,dihydrochlorothiazide(DHCT) 50mg Bid was instituted and a decrease of Uca during the second to the fourth week and a decreased tendency of Uox were noted.Of these treated patients.the Psf values decreased 0.24,0.39 and 0.35 during the second to the fourth week and all reached the normal range at the end of the fourth week.Immobilization increases the risk of urinary stone formation and DHCT provides an inhibitory effect on the stone formation in immobilized patients.