抗自身粒细胞抗体IgG与肾脏移植初探

Anti-granulocyte autoantibody IgG and renal transplantation

对２４例肾脏移植受者的血中抗粒细胞抗体ＩｇＧ进行动态测定。术前阳性２例，术后转阴。术后该抗体阳性病人５例，其中３例发生白细胞减少症，３例发生急性排斥反应，抗体阳性伴急性排斥与白细胞减少症有自身免疫因素参与。对于该抗体早期的阳性认为来自供体的过客细胞。对于抗粒细胞抗体阳性白细胞减少症，认为以加大糖皮质激素用量与使用免疫球蛋白为佳。

Anti-granulocyte autoantibody (AGAB) IgG was repeatedly assayed by chemoluminescent immunoassay and immuno-fluorescence test in 24 patients of kidney transplantation. In 2 of the patients,blood AGAB IgG was positive before operation but turned negative 2 weeks after transplantation. Blood AGAB IgG became positive after trnaplantation in 5 and neutropenia was noted in 3 of them, repeated acute rejections in 4.In 2 patients, both neutropenia and repeated acute rejections occurred. It was suggested that autoimmunity might also play a role in post-transplantation neutropenia and acute rejection of the transplant might have something to do with AGAB IgG.It was postulated that early posttransplantation AGAB IgG might be originated from passenger B cells.Glucocorticoid and immunoglobulin are indicated in autoimmune neutropenia.