正常前列腺和前列腺增生的组织形态学定量研究

A quantitative morphometry of the normal and the benign hyperplastic prostate in Chinese

利用ＨＥ染色和免疫组织化学染色结合计算机辅助图像分析的方法，对２０例尸检正常前列腺和２０例良性前列腺增生（ＢＰＨ）标本的组织构成成分进行了形态学的定量研究。正常前列腺组织的间质、上皮和腺管腔的面积百分比分别为５２．５０±１０．３９％、２８．５６±６．７６％、１９．０１±４．６２％，ＢＰＨ组织的上述三种成分各自所占的面积百分比分别为５６．８８±１０．１８％、１５．５２±３．５６％、２７．６０±９．１１％。ＢＰＨ的上皮增生以基底细胞的增生、肥大为特点，基底细胞由正常的扁平变为立方或矮柱状。ＢＰＨ间质所占比例较正常前列腺明显增加，同时，间质的构成成分也发生变化，平滑肌占间质的面积百分比（３４．１２±７．０５％）明显高于正常前列腺（２６．０３±８．５２％）。本研究结果提示中国人的ＢＰＨ组织构成比例可能不同于西方国家。

Computer-assisted quantitative image analysis was adopted to quantify the area density of stroma,epithelium,glandular lumen and smmoth musscle of 20 benign hyperplastic and 20 normal human prostates.The BPH tissues contained 56.38±10.39%,15.52±3.56%,27.60±9.11% and the normal prostate specimens contained 53.50±10.18%,28.56±6.76%,19.04±4.64% of stroma,epithelium and glandular lumen respectively.The percent area density of prostate smooth muscle in BPH stroma(34.12±7.05%)was much higher than that in normal prostate stroma 23.03±8.52%(P<0.01).It was suggested that there might be some difference between Chinese and western people in the components of BPH prostates.