摘要
16例接受膀胱镜检的患者分为临床碱化组和临床对照组;将20只家兔匀分为动物碱化组和动物对照组。碱化组均给予pH7.15的1%丁卡因溶液,对照组给予pH5.1的1%丁卡因溶液。结果,临床碱化组麻醉效果优于临床对照组(P<0.05)。但临床对照组药液在血液中达峰时间(Tpeak)快;峰浓度(Cmax)及血药浓度的各个时点均高于临床碱化组(P均<0.01)。两组中分布半衰期,消除半衰期无显著性差异。表现分布容积(Vd),药时曲线下面积(AUC)和清除率(CL)有显著性差异(P均<0.01)。动物碱化组丁卡因在血中浓度低,而在膀胱组织中浓度高(P均<0.01)。认为碱化丁卡因具有效果好,毒性低和清除快的优点,用于临床尿道粘膜表面麻醉安全有效。
Urethroscopy was undertaken for 8 patients under topical anaesthesia with 1% alkalized tetracaine(1.2mg/kg,PH 7.15).8 patients,served as controls,received the same dosage of tetracaine but with a PH of 5. 1.The anaesthesia effect of alkalized tetracaine was significantly better(P<0.05)while the plasma peak time was longer and the concentration peak was lower as compared with the controls(P<0.01).Alkalized tetracaine(pH 7.15)was safe and effective as a topical anaesthetic for urethra.
出处
《中华泌尿外科杂志》
CSCD
北大核心
1995年第12期747-749,共3页
Chinese Journal of Urology
关键词
麻醉
丁卡因
代谢解毒药物
尿道粘膜
药物动力学
Anaesthesia
local Tetracaine Pharmacokinetic Metabolic detoxication
drug