摘要
用鳗降钙素类似物──益钙宁治疗１０例次７例患者高钙血症。经７天观察，血钙在４小时及２４小时均显著降低，但４８小时回升到近治疗前水平，出现“脱逸”现象，随后几天血钙波动在较高水平。但到第６天血钙再次明显降低，停药后血钙２４小时内回升，与第６、７天相比，有显著差异（Ｐ＜０．００２和＜０．０５）．并发现益钙宁的降血钙作用主要通过抑制破骨细胞来实现。
In this article the effect of
calcitonin analogue (Elcitonin) on 10 episodes of hypercalcemia in 7 patients was observed.
Duringthe 7-day treatment with Elcitonin,serum calcium concentrations were significantly
lowered by 4 hours and 24 hours (P<0. 02).By 48 hours, however, serum calcium
concentrations returned nearly to pretreatment levels. In the following days, serum
calciumconcantrations remained at high levels,this is called the“escape phenomenonn”. By
the 6th day,serum calcium concentrations weresubstantially reduced again( P<0- ol).After
withdrawal of Elcitonin, serum calcium concentrations rose significantly within 24hours as
compared with those on 6th and 7th day, the difference were significant (P<0. 002 vs P<0.
05).This study suggests thatthe calcium-lowering effect of Elcitonin is mainly owed to the
effective suppression of osteoclast activity.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1995年第1期28-31,共4页
Chinese Journal of Endocrinology and Metabolism
