血管紧张素Ⅰ转换酶基因与中国人冠心病、糖尿病及高血压的关系

RELATIONSHIP BETWEEN ANGIOTENSINⅠCONVERTING ENZYME GENE AND CORONARY HEART DISEASE,DIABETES MELLITUS AND HYPERTENSION IN CHINESE

在冠心病（ＣＨＤ）、非胰岛素依赖型糖尿病（ＮＩＤＤＭ）及特发性高血压（ＨＴＮ）呈不同组合的２３１例中国人中研究血管紧张素Ⅰ转换酶（ＡＣＥ）基因与此三种疾病的关系，发现：（１）ＡＣＥ基因与中国人ＣＨＤ关联；（２）此种关联表现于ＡＣＥ基因插入／缺失（Ｉ／Ｄ）型多态中ＤＤ、ＤＤ＋ＤＩ基因型及Ｄ等位基因频率在ＣＨＤ中显著增高；（３）中国人普通群体中呈ＤＤ型者发生ＣＨＤ风险率为Ⅱ型的９倍；（４）在中国人中ＡＣＥ基因与ＣＨＤ的关联是一种普遍存在情况，此种关联亦见于ＨＴＮ或ＮＩＤＤＭ合并ＣＨＤ中，亦即ＨＴＮ或ＮＩＤＤＭ患者ＡＣＥ基因Ｉ／Ｄ基因多态呈ＤＤ型者易合并ＣＨＤ；（５）ＡＣＥ基因Ｉ／Ｄ多态是中国人ＣＮＤ发病独立风险因素。

The relationship between angiotensinⅠconverting erzyme (ACE)gene and coronary heart disease(CHD),non-insulin depen-dent diabetes mellitus(NIDDM)and essential hypertension (HTN)was investigated in 231 Chinese subjects with different combi-nations of these diseases. The results showed that:1)ACE gene was associated with CHD in Chinese;2)it was characterized by asignificant increase in the frequencies of DD, DD+DI genotypes and D allele of an insertion/deletion(I/D)polymorphism of ACEgene; 3)the risk for the development of CHD in individuals with DD genotype was nine times higher than those with II genotype ingeneral population; 4)the association of ACE gene and CHD was an universal phenomenon in Chinese. Such association was alsoobserved in HTN or NIDDM patients with CHD,i.e. NIDDM or HTN patients with DD genotype were more likely to developCHD; 5)the I/D polymorphism of ACE gene was an independent risk factor for CHD in Chinese.