肺心病患者血小板膜蛋白P－selectin与血小板功能的变化

THE RDLATIONSHIP BETWEEN P-SELECTIN ON PLATELET MEMBRANE AND PLATELET FUNCTION IN CHRONIC COR PULMONALE

采用同位素标记的单克隆抗体（￣（１２５）Ｉ－ＳＺ＿（５１））观察了３０例慢性肺心病患者血小板膜蛋白Ｐ－ｓｅｌｅｃｔｉｎ的变化及血小板粘附、聚集功能变化的关系。结果显示，慢性肺心病患者的血小板膜蛋白Ｐ－ｓｅｌｅｃｔｉｎ较慢性肺病组及与正常人群比较显著升高（Ｐ＜０．０１），同时与血小板的粘附功能、聚集功能具有良好的相关性（Ｐ＜０．０１），血浆中的ｖｏｎＷｉｌｌｅｂｒａｎｄ因子（ｖＷＦ）、纤维蛋白原水平升高并促进血小板粘附及聚集。

latelet pla ys an importent role in thrombombdic diseases,It is demonst ra ted that rec urrent pul-monary embOlism may cause pulmonary hypertention. In recent years,P-selectin (granule membrane pro-tein,GMP_(140) ) was found to be a surface marker for platelet activation. In order to investigate the role of platelet in chronic cor pulmonale,the changes of p-selectin on platelet membrane and its effect on platelet adhesivness(PAdT)and platelet aggregation ( PAgT ) were studied.The resuIts showd that the changes of p-selectin、PAdT and PAgT in chronic cor pulmonale were significant than those in chronic pulmonary diseases and controls(P<0.01). There was positive correlation between p·selectin and PADT(r=0. 6831,P<0. 01)as well as PAgT(r=0. 7142,P<0.01).The levels of von Willebrand factor(vWF)and fibrinogen (Fg)were markedly increased in chronic cor pulmonale as compared with chronic pulmonary disease and control group(P<0.01).There wa,also positive correlation between vWF and PAGT(r=0.4143, P<0, 05)as well as between Fg and PAgT(r=0. 4392, P<0. 05).It is concluded that platelet pfays an importent role in the pathogenesis of chronic cor pulmonale.