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心肌缺血预适应对缩小心肌梗塞范围的临床研究 被引量:51

A CLINICAL STUDY ON LIMITATION OF INFARCT SIZE BY ISCHEMIC PRECONDITIONING IN 100 CASES OF ACUTE MYOCARDIAL INFARCTION
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摘要 近年动物试验证明心肌缺血预适应有一种保护作用。本组分析了近3年我院急性前壁心肌梗塞110例病人缺血预适应对心肌梗塞的影响。其中男77例,女33例。心肌梗塞前有预缺血者69例(A组).,无预缺血者41例(B组)。资料分析显示:B组心肌梗塞时心肌坏死范围、心肌酶峰值、心功能损害、室壁瘤形成及死亡率均高于A组,两组差异有显著性。还就心肌缺血预适应发生时间及其对心肌保护作用之间的关系,缺血预适应的可能机制及临床意义进行了讨论。 he protective effect of ischemic preconditioning has heen confirmed in animal models. In this study we analyzed the clinical data of 110 cases of acute myorardial infarction(77male, 33 female). Sixty-nine cases(group A)had ischemic manifestations prior to myocardial infarction,while forty one (group B)did not have. Our data showed that the cIinical features in group B were quite different as compared with those in group A :(1)larger infarct size (ratio between necrotic size and ischemic size:71.55± 3.70 to 4l.65± 3. 96,P<0. 0001);(2)higher peak level of serum cardiac enzymes(CPK:2085. 78±265. 57 to 1329.80 ±189.44,P<0. 01; CK-MB:102. 73±12. 47 to 47. 38±8. 83, P<0. 01);(3)pcoier cardiac function [LVEF<0.45: 12/41 (29.3%)to 6/69(8.7%), P<0. 05] ; (4) higher incldence of left ventricular aneurysm[9/41 (22.0%)to 3/69 (4.3%), P<0.05] and(5)higher mortality rate in 4 weeks[6/41(14.6%)to2/69 (2.9%),P<0. 05].The difference between the two groups is statistically significant.In addition,the effect of the duration of preconditioning on protection of myocardium,the potential mecha nism of preconditioning and its clinical significance were discussed.
出处 《中华内科杂志》 CAS CSCD 北大核心 1995年第1期16-18,共3页 Chinese Journal of Internal Medicine
关键词 心肌梗塞 缺血预适应 心肌缺血 Myocardium Myocardial infarction Ischemic preconditionig
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