甲状腺疾病患者血清TSAb和TBII的检测

DETECTION OF THYROED STIMULATING ANTIBOKIES AND TSH BINDING INHIBITOR IM-MUNOGLOBULINS IN PATIENTS WITH THYROID DISEASES AND ITS CLINICAL APPICATIONS

采用细胞培养生物学方法和放射受体分析法检测甲状腺疾病患者血清甲状腺刺激抗体（ＴＳＡｂ）和促甲状腺激素结合抑制免疫球蛋白（ＴＢＩＩ）。发现Ｇｒａｖｅｓ病未治组ＴＳＡｂ和ＴＢＩＩ活性与阳性率明显高于Ｇｒａｖｅｓ病缓解组和桥本甲状腺炎（ＨＴ）组，后两组ＴｓＡｂ和ＴＢＩＩ活性与阳性率高于甲状腺腺瘤组和正常对照组。Ｇｒａｖｅｓ病未治组、缓解组和ＨＴ组其ＴＳＡｂ和ＴＢＩＩ的检出率分别为９１．７％和７９．２％、４８．０％和４４．０％及２３．１％和６１．５％。甲状腺腺瘤组和对照组ＴＳＡｂ和ＴＢＩＩ均为阴性，其活性亦无统计学差异。血清ＴＳＡｂ与ＴＢＩＩ活性以及ＴＳＡｂ、ＴＢＩＩ活性与Ｔ＿３、Ｔ＿４、ＦＴ＿３和ＦＴ＿４浓度之间均无显著相关性。提示ＴＳＨ受体抗体具有异质性，联合检测这两种抗体对了解自身免疫性甲状腺疾病（ＡＩＴＤ）的发病机理，合理诊治甲状腺疾病具有重要的临床价值。

hyroid stimulating antibodies (TSAb)and TSH binding inhibitor immunoglobulins(TBII)were as-sessed in patients with thyroid diseases,The activity of TSAb and TBIl was significantly higher in patients with untreated Gravesl disease (GD)as compared with that in patients with remitted GD and Hashimoto's thyroiditis,while the latter two groups had higher TSAb and TBII activity than patients with thyroid ade-noma or control suUects.Of 24 patients with untreated GD, TSAb and TBII were detected in 22 and 19 respectively. The positive rates of TSAb and TBII in patients with ren1itted GD or Hashimoto' s thvroditis were 0. 48 and 0.44 or 0.231 and 0.615.Both TSAb and TBII were negative in patients with thyroid ade-nolna or controls. No statistical correlation was found between TSAb and TBII activity,suggesting the co-existence of heterOgeneous populations of TSH receptor antibedies