饮食和运动干预治疗对糖尿病发病率的影响──530例糖耐量低减人群六年前瞻性观察

EFFECT OF DIETARY AND/OR EXERCISE INTERVENTION ON INCIDENCE OF DIABETES IN 530SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE FROM 1986～1992

对１９８６年在大庆人群糖尿病调查诊断的５７７例糖耐量低减（ＩＧＴ）者按体重指数（ＢＭＩ））２５（３５２例）及＜２５（２２５例）分组基础上再随机分为人数相等的对照、饮食、运动及运动加饮食干预治疗组。６年前瞻性观察证明，在各组年龄、ＢＭＩ、空腹及服糖后２小时血糖相当的基础上，对照组、饮食、运动、饮食加运动干预治疗组的糖尿病人年发病率分别为１５．７％、１０．０％，８．３％及９．６％。多因素分析调整年龄、ＢＭＩ及血糖等重要糖尿病发病因素后，仍证明上述干预治疗有肯定的降低糖尿病发病率作用。实际干预治疗越好，人年发病率越低，证明对ＩＧＴ者进行饮食和（或）运动治疗是减少糖尿病发病率的有力措施。

7 7 subjects with impaired glucose tolerance(IGT)aged from 2 5 to 74were identified in Daqing in1986.They were stratified according to BMI≥25 ( 352 cases) and BMI<25(225 cases)and suUects in each BMI group were randomly assigned to four groups:control,diet,exercise and diet plus exercise inter vention groups(each group had similar age, BMI, fasting and 2-hour plasma glucose level).Asix-year follow up study indicated that incidence of diabetes per 100-person-year was 15.7, 10.0,8. 3 and 9. 6 in control,diet,exercise and diet plus exercise groups respectively. Proportional hazards regression analysis controlling for differences in baseline factors age,sex, BMI and plasma glucose)showed that diet and/or exercise intervention were inversely reiated to the incidence of diabetes.The better the actual intervention,the less the incidence of diabetes.Therefore,the resuls strongly indicate that diet and/or exercise inter-vention treatment are effective methods to reduce the incidence ot diabetes