摘要
合成了油菜甾醇内酯A/B环类似物2α,3α-二羟基-6-胆甾醇(7)。以胆甾醇为起始物,经硝化和还原水解等步骤,得3-羟基-6-羰基胆甾烷(4),按常规法苯磺酰化,消?苯磺酸得6-羰基-2-胆甾烯(6),用OsO_4氧化后得目的物(7)。总产率43.6%。该方法具有总产率高,步骤少和后处理简便等优点。
This paper presents the synthesis of A/B rings of Brassinolide analogue. Taking cholesterol as starting material, nitration and reduction-hydrolysis as key steps, 3-hydroxy-6-cholesterone (4) was obtained in good yield. (4) was then sulphonylated and desulphonated by the usual ways to 2-steroidal alkene (6) which was oxidized by OsO4 giving the target product 2α, 3α-dihyd-roxy-6-cholesterone (7) with a total yield of 43.6%. Compared to the previous metnods, the present synthesis has several advantages such as higher total yield, fewer reaction steps, aad pure products more easily obtained
出处
《厦门大学学报(自然科学版)》
CAS
CSCD
北大核心
1989年第3期284-287,共4页
Journal of Xiamen University:Natural Science
关键词
油菜甾醇内酯
A/B环
合成
Brassinolide, A/B rings analogue, Synthesis