慢性呼吸衰竭病人红细胞膜带3蛋白阴离子转运功能的研究

A STUDY ON ERYTHROCYTE MEMBRANE BAND 3 PROTEIN ANION TRANSPORT FUNCTION IN CHRONIC RESPIRATORY FAILURE PATIENTS

为探讨慢性呼吸衰竭（呼衰）病人红细胞膜带３蛋白（ｂａｎｄ３ｐｒｏｔｅｉｎ）阴离子转运位点结构及转运功能的变化规律，评价ＨＣＯ＿３／Ｃｌ￣－交换对肺心病呼衰病人体内ＣＯ＿２潴留的影响，对慢性呼衰病人８０例和健康人３７例的红细胞膜带３蛋白结构、含量和阴离子转运功能，红细胞内外血气和电解质进行了同步观测。结果表明，肺心病Ⅱ型呼衰病人带３蛋白阴离子转运功能明显降低，使ＨＣＯ＿３／Ｃｌ￣－交换受限，ＣＯ＿２排出减少，可能是加重Ⅱ型呼衰病人ＣＯ＿２潴留和呼吸性酸中毒的原因之一，肺心病Ⅱ型呼衰病人带３蛋白阴离子转运功能降低是可逆的。因此，及时纠正缺氧，改善低氧状态，也许有助于阴离子转运功能的恢复。

he changes of the structure,content and anion transport function as well as the blood gases and elec-trolytes inside and outside the erythrocytes were investigated in 3 groups of subjects:type Ⅰ respiratory fail-ure patients (group 1.n=40);type Ⅱ respiratory failure patients (group 2,n=40) and controls (group 3,n=37)。The results showed that(1) anion transport function impairment of erythrocyte membrane band 3 protein and HCO3/Cl￣- exchange restrain may be the reasons that aggravate CO_2 retention and res-piratory acidosis in cor pulmonale patients with type Ⅱ respiratory failure,(2)band 3 protein anion trans-port function impairment in patients of cor pulmonale with type Ⅱ respiratory failure is reversible. There-fore,it was necessary to supply oxygen to cor pulmonale patients with hypoxemia in time,which may con-tribute to the recovery of anion transport function.