脑梗塞早期患者血纤溶系统活性状态分析

AN ANALYSIS ON THE ACTIVITY STATUS OF FIBRINOBYTIC SYSTEM IN CHINESE PATIENTS WITH ACUTE CEREBRAL INFARCTION

为明确血纤溶系统活性状态与脑梗塞发病的关系，采用病例对照研究方法，对３０例皮质动脉区脑梗塞（ＣＡＣＩ）患者、３２例穿通动脉区脑梗塞（ＰＡＣＩ）患者及３０名无心脑血管病等的对照者，以发色底物分解产色法测定血浆组织型纤溶酶原激活物（ｔＰＡ）活性、纤溶酶原激活物抑制物（ＰＡＩ）活性及血管内皮ｔＰＡ释放能力和ＰＡＩ／ｔＰＡ比值，以综合判定其血纤溶系统活性，结果表明两种类型脑梗塞患者发病３天内血纤溶系统活性均显著低于对照者，为脑梗塞早期行溶栓治疗提供了理论依据。同时提出，再次脑梗塞可能与血浆ＰＡＩ活性高有关。

he fibrinolytic activity status of the patients with cerebral infarction can affect their clinical progno-sis. In this case-controlled study,the plasma fibrinolytic system activities in 30 cases of cortical artery terri-tory cerebral infarction(CACI)and 32 cases of perforating artery territory cerebral infarction (PACI) with a disease duration less than 3 days were assayed with a comprehsive panel including the plasma tPA activi-ty, PAI activity,tPA releasing capacity from vascular endothelium and PAI/tPA ratio values. 30 subjects without cardiovascular and cerebrovascular disorders were served as control.The results showed that the plasma fibrinolytic system activities of the patients with aforementioned two subtypes of cerebral infarction were significantly lower than those of the controls,the results provide a theoretical basis for carrying out thrombolytic therapy in patients with ischemic stroke and suggest that recurrent cerebral infarction might be related to the high activity of plasma PAI.