黄芪与当归对肾病综合征患者总体蛋白质代谢的影响

A STUDY ON PROTEIN METABOLBOLISM IN NEPHROTIC PATIENTS TREATED WITH CHINESE HERBS

为探讨黄芪与当归对肾病综合征患者蛋白质代谢紊乱的治疗机理，我们用稳定核素示踪动力学研究方法和氮平衡技术，观察了黄芪与当归在富蛋白饮食基础上对肾病综合征，患者总体蛋白质代谢动力学参数及氮平衡的影响，发现患者在治疗前体内氮更新率，氮平衡状态均处于高水平；治疗后二者均呈下降趋势（Ｐ＜０．０１），而蛋白质净合成率（蛋白质合成率／蛋白质分解率）明显增加（Ｐ＜０．０５），血浆总蛋白、白蛋白水平明显增加（Ｐ＜０．０５）。表明黄芪、当归可纠正肾病综合征患者蛋白质代谢紊乱，并通过促进患者蛋白质净合成，提高其血浆蛋白水平，从而改善其机体状况。

It was found in our previous studies that two Chinese herbs Astragali and Angelica( A&A)together with high protein diet could ameliorate the lowering of serum albumin level and mankedly increase the syn-thesis rate of protein as shown by ￣(15)N-glicine tracer priming protein turnover study in nephrotic rats:Further experiment was designed to investigate the role of A&A and high protein intake in protein dynamicstudy and nitrogen balance in nephrotic patients The level of serum total protein (STP),serum albumin(SA),urinary protein loss(UP), serum cholesterol (Cho)and index number of protein turnover and ni-trogen balance in 7 patients were measured before and after treatment of 30 days with A&A. The resultsshowed that after treatment the patients had significantly increased STA and SA(44.3±5.60 vs 49.7±6.80 P<0.01;22.6±0.42 vs 29.4±7.40 P<0.05),decreased UP and Cho(6.54±1.83 vs 4.63±1. 33 P<0.05; 9.69±2.31 vs 7.82±1.95 P<0.05)and increased net rates of total protein synthesis(1.06±0.03 vs 1.27±0.12 P<0.05).It is concluded that A&A together with high protein intake could im-prove the disorder of protein matabolism and increase the level of serum protein by improving the net rateof protein synthesis in nephrotic patients.