结直肠癌和息肉病人中的T抗原的检测

DETECTION OF T-ANTIGEN IN COLORECTAL ADENOCARCINOMA AND POLYPS

为验证Ｔ抗原检测对结直肠癌普查的价值，用Ｓｈａｍｓｕｄｄｉｎ和Ｅｌｓａｙｅｄ介绍的半乳糖氧化酶法，对１５６例不同对象的直肠粘液标本进行Ｔ抗原检测。结果发现，３２份结直肠癌和５５份结直肠息肉病人的标本中，Ｔ抗原阳性率分别为８４．４％和２９．１％，与６９份对照组标本的阳性率（７．２％）相比，差异均有极显著性（Ｐ＜０．００１和Ｐ＜０．０１）。Ｔ抗原检测在已确定的结直肠癌中，敏感性为８４．４％，特异性为９２．８％。Ｔ抗原检测方法简便，结果易重复，且具有较高的敏感性和特异性，因此，颇具潜在的结直肠癌筛选普查的应用价值，同时也为结直肠息肉的筛选提供了一种可供选择的方法。

alactose oxidase method was employed to detect the β-D-Gal ( 1→3)-D-Gal NAc residue of T-anti- gen present in the large intestinal mucus of 156 subjects. The positive rates of the test were 84.4%,29. 1%,and 7.2% in the mucus samples obtained from 32 patients with colorectal adenocarcinomas,55 with polyps and 69 controls respectively. Chi-square test demonstrated that there were significant differences be- tween the group of carcinoma and control(P<0.001)as well as between also polyp and control ( P< 0.01).The test had a high sensitivity(84.4%)and specificity(92.8%)in the diagnosis of colorectal can- cer and may be used as a practical mass screening test for colorectal neoplasms.