血胰岛素与少年儿童高血压及盐敏感性的关系

ASSOCIATION OF PLASMA INSULIN WITH BLOOD PRESSURE AND SODIUM SENSITIVEITY IN CHILDREN

为研究血胰岛素与儿童高血压及盐敏感性的关系，对陕西汉中心血管病防治区经５年随访，年龄１０～１５岁的一组少年儿童共３００名，进行了血浆胰岛素测定及口服盐水负荷试验。发现血压偏高及家族史阳性者，胰岛素明显高于血压正常及家族史阴性者（Ｐ＜０．０１）；胰岛素偏高组５年间收缩血压百分位数保持较高百分位次或呈上升趋势；胰岛素水平与钠负荷及利钠后血压变化幅度正相关（Ｐ＜０．０５）。提示胰岛素抵抗／高胰岛素血症与盐敏感性相关联，在少儿时期已发挥作用，参与高血压的始动机制。

o study the relationship between plasma insulin level,sodium sensitivity and blood pressure,150childen aged from 10 to 15 years with high blcod pressure and 150 children matched for age and sex butwith normal blood pressure were measured for plasma insulin with radioimmunoassay and sodium sensitivitywith the tests of oral saline load and furosemide sodium-volume depletion and followed for 5 years,The re-sults showed that(1)In children with HBP and positive family histry of hypertension(FH+),the plasmainsulin level was significantly higher than that in the respective control group(P<0.01);(2)In childrenwith high plasma insulin level,the percentiles of systolic blood pressure kept high and had a rising tendencyduring the follow-up period;(3) In children with sodium sensitivity, the plasma insulin level was higherthan that in children with sedium resistance(P<0. 01)and the plasma insulin level correlated positivelywithblood pressure increasing rate of post-load( P<0.05).It is suggested that insulin resistance wasassociated with sodium sensitivity, and they might play a role in the development of hypertension inchildhood.