高原心肌低氧症患者血浆肾素系统和心钠素的变化

THE SIGNIFICANCE OF CHANGES IN PLASMA RENIN ANGIOTENSIN ALDOSTERONE SYSTEM AND ATRIAL NATRIURETIC FACTOR IN PATIENTS WITH HIGH ALTITUDE MYOCARDIAL HY-POXIDOSIS

为研究高原心肌低氧症患者血浆肾素系统和心钠素的变化，对３０例高原心肌低氧症（ＨＡＭＨ）患者用放免法测定了血浆肾素活性（ＰＲＡ）、血管紧张素ＩＩ（ＡＩＩ）、醛固酮和心钠素（ＡＮＦ）含量，结果发现ＨＡＭＨ患者血浆ＡＩＩ与ＡＮＦ间浓度比例与慢性高原心脏病、长期移居高原健康成人明显不同。并讨论了这些生物活性物质紊乱可能在ＨＡＭＨ发生发展中的作用。

plasma renin activity(PRA),angiotensin H(ATH),aldosterone(ALD)and atrial natriuretic factor( ANF )were determined in 30 patients with high altitude myocardial hypoxidosis(HAMH ) with radioim-munoasay and the data were compared with those of 40 healthy subjects and 26 patients with high altitude chroric cardiopthy(HACC).All of them have heen in Lasa, a place with an altitude of 3 658 meter,for a long time,The results showed that PRA and plasma ATH increased significantly (P<0. 05～0. 01)and plasma ANF decreased soignificantly(P<0. 01)in patients with HACC and were higher than those in the control.It is suggested that disturbance of these biologically active substances might play a role in the de-volopment of HAMH.