摘要
为观察国产氟康唑胶囊剂治疗深部真菌病的临床疗效与安全性，用国产氟康唑胶囊治疗深部真菌感染９１３例。氟康唑每日剂量１００～２００ｍｇ，疗程３６～８个月。结果：痊愈率和总有效率分别为６９．２６％与９４．２９％，真菌清除率为９３．８３％。主要不良反应为恶心、呕吐、腹泻、腹痛等消化道症状，多可耐受，不良反应发生率为９．２０％。本临床试验表明，国产氟康唑胶囊剂为一有效、安全的治疗深部真菌感染的药物。
A multiple center clinical trial was conducted to evaluate the efficacy and safety of domestic fluconazole in treating 913 cases of deep-seated fungal infections. Fluconazole was given 100～200mg daily for 3 days to 8 months. The results showed that the cure rate and the total efficacy rate were 69. 26%and 94.29%respectively. The fungal clearance rate was 93. 83%. The main side-effects were nausea, vomiting,diarrhea and abdominal pain, but most of the patients could endure. The side-effect rate was 9. 20%,This clinical trial indicated that domestic fluconazole was effective and safe in treating deep-seated fungal infections.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1995年第12期823-826,共4页
Chinese Journal of Internal Medicine
