胰腺移植对大鼠糖尿病早期肾病的治疗

The treatment of pancreas transplantation for incipient nephropathy in diabetic rats

通过对大鼠肌注链脲霉素制成稳定的糖尿病模型后，尿中２４小时β２－微球蛋白、白蛋白排泄总量的检测，发现其均明显地高于正常水平，最高可达正常１０倍左右；并对胰腺移植后尿中增高的β２－微球蛋白、白蛋白，肾重／１００克体重恢复情况进行观察，认为成功的胰腺移植可以使糖尿病早期肾病的微量蛋白尿和增大的肾脏体积恢复正常。

The 24hr urine B2-microglobulin(B2-mG)and albumin(Alb)in streptosotocin(STZ)-induced diabetic rats exceeded the normal level by about ten times.The changes of B2-microglobulin,albumin and kidney weight/100g body weight after pancreas transplantation were also observed.The results showed that pancreas transplantation could reverse the proteinuria and renal enlargment of the diabetic incipient nephropathy.