肾移植患者血浆一氧化氮浓度的观察

Plasma nitric oxide in patients with renal transplants

采用微盘比色法，通过对一氧化氮代谢产物亚硝酸盐的测定，对３２例尸体肾移植患者术前及术后３个月的血浆一氧化氮（ＮＯ）水平的变化进行了动态观察；同时，对血浆内皮素（ＥＴ）、环孢素Ａ（ＣｓＡ）、肌酐（Ｃｒ）、尿素氮（ＢＵＮ）及血压亦做了监测。结果：肾移植前血浆ＮＯ浓度为２４．０１±１．１５μｍｏｌ／Ｌ，显著高于术后３个月内各阶段（Ｐ＜０．０１），血浆ＥＴ、ＢＵＮ和血压亦呈相似的变化趋势，并与ＮＯ呈显著相关。作者认为肾移植后ＮＯ浓度测定不仅有助于了解肾移植后肾损伤的机理，亦可作为一项肾功能监测的参考指标。

AbstractThe plasma nitric oxide (NO) in 32 patients withrenal allografts was observed before transplantationand in the early period of three months after transplan-tation. Endothelin(ET ) ,cyclosporin A blood concen-tration,Creatinine(Cr),blood urea nitrogen ( BUN )were measured simuItaneously. The results showedthat plasma NO level ( 24.01±1.15μmol/L)beforetransplantation was significantly higher than that aftertransplantation. There was significant correlation be-tween plasma NO level and ET,Cr, BUN and bloodpressure. We consider that plasma NO concentrationmay reflect the function of renal transplant and play animportant role in early renal injury after kidney trans-plantation.