国产乙型肝炎血源疫苗免疫持久性观察

Observation of Immunity-Persistence of Natively-manufactured Hepatitis B Plasma-derived Vaccine

对１０６９名儿童乙型肝炎血源疫苗免疫后抗乙型肝炎病毒表面抗原的抗体（抗－ＨＢｓ）水平进行检测，结果表明，抗－ＨＢｓ阳转率为９４．３％；初免后５年抗－ＨＢｓ阳转率仍可保持为９２．３％；不同初免年龄免疫后抗－ＨＢｓ阳转率和持续时间未见明显差异。提示：为减少我国乙型肝炎发病率和乙型肝炎病毒携带者，用乙肝疫苗免疫接种是防止ＨＢＶ传播最有效的措施，经过正确接种疫苗后约９５％的接种者可具有免疫力；新生儿和婴幼儿接种乙型肝炎疫苗后至少５年不需要加强免疫。

Antibodies to HBsAg were detected in sera of 1069 children who were inoculated with hepatitis B(HB) plasmaderived vaccine. Results showed that positive-conversion rate of anti-HB was 94.3%. Positive-conversion rate of anti-HBs 5 years after primary immunization was still 92.3%. No significant difference was seen between positive-conversion rate of anti-HB and immunity-persistence among children at different years of age after primary immunization. Suggested that in order to reduce the incidence of hepatitis B and hepatitis B virus (HBV) carriers, inoculation of HB vaccine may be the most effective way to prevent from transmission of HBV. An average of 95% of them who received proper inoculation of the vaccine should acquire the immunity. where as neonates and children need no intensive immunization after inoculation of HB vaccine for five years.