银屑病患者人巨细胞病毒感染的研究

Study on Human Cytomegalovirus Infection in Patients with Psoriasis

用高敏感性酶联免疫吸附法和多聚酶链反应（ＰＣＲ）技术分别检测了８６例银屑病患者血清特异性人巨细胞病毒（ＨＣＭＶ）－ＩｇＭ和ＨＣＭＶ－ＩｇＡ及尿ＨＣＭＶ－ＤＮＡ的变化。结果显示，银屑病患者活动性ＨＣＭＶ感染率和尿ＨＣＭＶ－ＤＮＡ阳性率分别为５５．８％和２４．４％，而对照组则为４．０％和０，两组相比有显著性意义（Ｐ＜０．００１）。提示活动性ＨＣＭＶ感染与银屑病有一定关系。

IgM and IgA antibodies against human cytomegalovirus (HCMV) and urine HCMV- deoxyribonucleic acid (HCMV-DNA) were examined in the serum and urine respectively from 86 patients with psoriasis by using enzymewlinked immunosorbant assay (ELISA) and polymerase chain reaction (PCR). Active HCMV infection and positive rate of HCMV--DNA in the urine were found in 55. 8% and 24. 4% of patients respectively, but the rates were only 4. 0% and 0 in normal subjects (P O. 001 ). The results indicate that psoriasis is related to active infection of HCMV.