寻常型银屑病患者表皮细胞DNA含量检测及其临床意义

Detection of Epidermal Cellular DNA Content and its Clinical Significance in Psoriasis Vulgaris

用流式细胞仪检测１４例正常皮肤和３６例寻常型银屑病患者皮损及非皮损的表皮细胞ＤＮＡ含量。结果表明，表皮细胞增殖活性在止常皮肤、银屑病非皮损和皮损中依次增高，且差异有显著性（Ｐ＜０．０１）。结合临床、组织病理和６例患者治疗前后自身对比，对以上改变的临床意义提出讨论。

Detection of epidermal cellular DNA content by flow cytometry was performed in normal skin of 14 individuals, both lesiona] and nonlesional areas of 36 patients with psoriasis vulgaris. The results showed that the proliferative activity of epidermal cells was increased successively in normal skins, nonlesional and lesional skin of patients. The differences were significant (P O.01). In combination with the clinical features and histopathological changes and the comparison of 6 patients before and after treatment, the clinical significance of above changes has been discussed.