皮肤恶性淋巴瘤核形态测量和增殖率研究

Study on Karyomorphometry and Proliferating Rate of Cutaneous Malignant Lymphomas

对29例皮肤恶性淋巴瘤(CML)和7例皮肤淋巴样细胞浸润性疾病(CLI)中各例同一皮肤活检石蜡包埋标本同时回顾性检测核形态和增殖率,结果示统计学上CML的核体积(NVs)、银染核仁组成区蛋白计数(AgNORs)和增殖细胞核抗原(PCNA-PC10)指数(PC10Is)与CLI的差异有权显著意义。NVs和PC10Is与患者死亡相关。NVs与AgNORs也相关。

The same paraffin-embedded specimen of skin biopsy from each of 29 patients with cutaneous malignant lymphomas (CML) and 7 patients with cutaneous lymphoid infiltrates (CLI) was estimated simultaneously and retrospectively by karyomorphometry and proliferating rate assay. The results showed that the differences in nuclear volumes (NVs), count of argyrophilic nucleolar organizer regions(AgNORs) and proliferating cell nuclear antigen (PCNA-PC10) indices (PC10Is) between CML and CLI were statistically very significant. The NVs and PC10Is were correlated to the death rate of patients. NVs were also correlated to AgNORs.