c-erbB-1及c-erbB-2癌基因蛋白在皮肤基底细胞癌与鳞状细胞癌中的表达

The Expression of c-erbB-1 and c-erbB-2 Oncoproteins in Basal Cell Carcinoma and Squamous Cell Carcinoma of Skin

应用免疫组化技术研究43例基底细胞癌(BCC)、26例鳞状细胞癌(SCC)中c-erbB-1及c-erbB-2癌基因蛋白表达。结果表明:①BCC组织中c-erbB-1蛋白表达均有不同程度增强;而c-erbB-2蛋白仅在部分BCC中表达,且明显减弱。②SCC组织中c-erbB-1及c-erbB-2蛋白表达分别与肿瘤组织分化程度呈负相关及正相关。提示c-erbB-1及c-erbB-2癌基因蛋白异常表达可能对BCC及SCC发展起一定作用。

The expression of c-erbB-1 and c-erbB-2 oncoproteins were investigated by immunohistochemical technique using monoclonal antibodies to c-erbB-1 and c-erbB-2 oncoproteins in 43 cases of hasal cell carcinoma (BCC) and 26 cases of squamous cell carcinoma (SCC). The results showed that: ① The expression of c-erbB-1 oncoprotein in BCC increased; the expression of c-erbB-2 oncoprotein in BCC reduced significantly, and lost in 16 cases (16/43). ② The intensities of c-erbB-1 and c-erbB-2 oncoprorein expression had negative and positive correlations to the degrees of SCC differentiation respectively. It is suggested that the abnormal expression of c-erbB-1 and c-erbB-2 oncoprotein in BCC and SCC may play a role in the development of skin tumors.