小肠移植后排斥反应的监测

Rejection monitoring in small bowel transplantation

检测猪同种异体小肠移植后受体的血浆Ｎ－乙酰氨基已糖酶、外周血单个核细胞前凝血质活性、血清肿瘤坏死因子、血清白细胞介素２和白细胞介素６，并与同期的粘膜活检结果作对照，发现它们在排斥早期即有显著升高，其中单个核细胞前凝血质活性和白细胞介素２的变化早于排斥反应的病理变化，提示术后检测这些指标将有助于排斥反应的早期诊断。

The Plasma levels of N-acetyl hexosaminidase (NAG), peripheral blood monocyte Procoagulant activity (PCA), Values of serum tumor necrosis factor (TNF),interleukin 2(IL-2) and interleukin 6(IL-6)were detected in 15 Pigs following small bowel allotransplantation. The tesults showed that all of them had some degree of Value in the early diagnosis of rejection when compared with the mucosul biopsy of the graft, and that the changes of PCA and IL-2 occurred earlier than mythological change in rejection, which suggested that the detection of the substances above was Valuable in the early diagnosis of rejection in small bowel transplantation.