摘要
将60例肝硬化患者配对分成2组,对照组接受利尿剂和血制品治疗,移植组加用肝内胎肝细胞移植。3个月后,移植组肝功能Child分级,级等提高例数显著高于对照组(P<0.05),平均随访2.8年,移植组恢复工作的例数大于对照组,死亡例数小于对照组,差异非常显著(P<0.01);移植后检测血清甲胎蛋白水平,有助于疗效的判断,血清甲胎蛋白水平越高,疗效越好,移植前后外周血细胞及乙型肝炎病毒标记物无显著变化。
Intrahepatic transplantation of human fetal liver cells were conducted in thirty patients with posthepatitic liver cirrhosis.The case number with improved liver function (by child-pugh classification) and the survivors with inactive liver illness during 2 to 4. 5-yr followup period after transplantation were greater than those in the control group(P<0.05 and P<0.01,respectively).The elevation of serum AFP after transplantation predic ted a good recovery.This procedure did not increase peripheral blood cell counts and did not affect the conversion of serum hepatitis B virus markers either.The side effects included chilled fever (2.3%),right epiquadrant pain (7.8 %),collapse(0. 7%) and abdominal bleeding (0.7%).The indication and contraindication of the therapy and the management of side effects were discussed.
出处
《中华器官移植杂志》
CAS
CSCD
1995年第2期75-76,共2页
Chinese Journal of Organ Transplantation
关键词
肝硬变
胎肝细胞移植
治疗
Liver cirrhosis Human fetal liver cell Therapy Transplantation