HLA配型对移植肾功能恢复的影响

Influence of HLA matching to the recovery of renal graft function

为了探讨ＨＬＡ配型对移植肾功能恢复的影响，对２５例肾移植患者术前进行了ＨＬＡ配型，术后测定尿视黄醇结合蛋白（ＲＢＰ）的含量来评价肾功能的恢复情况。结果表明，与血清肌酐相比，ＲＢＰ能更准确地反映肾功能的状态，ＨＬＡ有１个以上ＤＲ位点相配者，术后１个月有９／１１的患者ＲＢＰ低于原始值的１０％；有１个以上Ｂ位点相配者，术后１个月有７／８的患者ＲＢＰ低于原始值的１０％；而无或仅有１个Ａ位点相配者，术后１个月仅有３／６的患者ＲＢＰ低于原始值的１０％。结果表明，ＨＬＡ－Ｂ、ＤＲ配型较好者术后肾功能的恢复情况明显优于配型不佳者。

In order to research the influence of HLA match to the recovering of renal function after renal transplantation, the data of HLA match and uric RBP from 25 patients were collected. The results were shown that retinol-binding protein (RBP) was more sensitive than serum Cr to reflect renal function. One month postoperation, the uric RBP value less than 10% of original value, in one or more DR matched patients, was 9 of 11; in one or more B matched patients, was 7 of 8; in one A or zero matched patients was only 3 to 6.Conclusion : the recovering of renal function after graft in HLA-B, DR matched patients was much better than HLA-B, DR mismatched patients.