肾移植后贫血改善机制研究

Mechanism of anemia improvement by renal transplantation

通过本中心透析移植患者各３０例及３０例正常人的对照研究，表明透析组患者均有不同程度的贫血，而移植组贫血得到明显改善；分别测定三组的血促红细胞生成素（ＥＰＯ）浓度，正常人组为１２５．１９±３８．０４ｐｇ／ｍｌ，透析组为１１６．５８±３０．７５ｐｇ／ｍｌ，而移植组为１８１．０８±６４．０５ｐｇ／ｍｌ，说明终末期肾病（ＥＳＲＤ）患者与正常人相比血ＥＰＯ浓度并无明显降低，而肾移植患者血ＥＰＯ却明显升高，其贫血的改善与ＥＰＯ有关。

Thirty dialytic patients with end stage renal disease (ESRD) and thirty renal allograft recipients(TX)were compared with normal controls.Anemia was only found in ESRD group,and it was mostly corrected in TX group.Serum EPO was also measured in three groups:125.19±38.04pg/ml in control group,116.58±30.75pg/ml in ESRD group,181.08±64.05pg/ml in TX group.No significance of serum EPO was found between ESRD and control(P>0.05).The serum EPO in TX group was much higher than that in ESRD and control group(P<0.001).It was shown that the improvement of anemia in TX was related to the more secreation of EPO.