事件相关电位N_（400）与精神分裂症

N_(400) component of event-related potentials and schizophrenia

作者对２３例服药精神分裂症和２０例未服药精神分裂症及２０例正常受试者，记录事件相关电位Ｎ_（４００）。受试者均接受视觉词意分类作业。结果显示，精神分裂症组Ｎ_（４００）波幅较对照组低，潜伏期延长３０～１００ｍｓ。随病情好转，精神分裂症Ｎ_（４００）波幅逐渐增大，其潜伏期缩短。而未服药组Ｎ_（４００）波波幅更小且形状不规则，潜伏期延长５０～１００ｍｓ。精神分裂症组Ｎ_（４００）潜伏期与阴性症状评定量表得分呈正相关。精神分裂症组Ｎ_（４００）与抗精神病药物剂量无关。精神分裂症组Ｎ_（４００）地形图显示以左颞叶不活跃，提示精神分裂症病人有左颞叶结构的异常。

Abstract:23 medicated and 20 non-medicated schizophrenics as well as 20 normal subjects were recorded for N_(400)component of event-related potentials.The semantic categorization task (visual)was carried out in each test. The results showed that there were decreased N_(400) were amplitudes and prolong from 30 ms to 100 ms in N_(400) latency in medicated schizophrenics in comparison to the normal group. Irregular N_(400)wavefrom might be found in non－medicated schizophrenics, which indicated the schizophrenics could not create the right expectancy to little priming. The N_(400)latency was in positive correlation with the SANS score in schizophrenia,N_(400) mapping demonstrated that there were no N_(400) activities in the left temple lobes which suggested that there were probably abnormal structural changes in the left temple lobes in the schizophrenics.