实验性迟发性脑动脉痉挛与几种血液成分的关系

Relation between delayed cerebral arterial spasm and the blood fractions

将新鲜动脉血制备成富血小板血浆（ＰＲＰ）、贫血小板血浆（ＰＰＰ）、完整红细胞（ＩＲＢＣ）、裂解红细胞（ＢＲＢＣ）与孵育动脉血（ＩＡＢ）五种成分，通过显微摄像系统动态观察其对正常与迟发性脑动脉痉挛（ＤＣＶＳ）狗基底动脉的收缩作用。结果表明，ＰＲＰ、ＢＲＢＣ、ＩＡＢ均能使正常狗基底动脉产生明显收缩，而只有ＩＡＢ能导致ＤＣＶＳ狗的痉挛动脉再产生收缩。

Abstract In this paper the blood fractions causing delayed cerebral arterial spasm(DCVS) were studied. The fresh arterial blood fractions including platelet-rich plasma(PRP). plateletpoor plasma(PPP), intact red blood cells(IRBC), broken red blood cells(BRBC), incubated arterial blood(IAB) were prepared.The basilar arteries and its braches of canines with and without DCVS were directly measured by aid of a operating microscope and a television microscope in vivo. Vasoconstriction was not induced by application of IRBC.PPP in both groups. The significant vasoconstriction was induced by application of BRBC,PRP to the basal arteries without DCVS rather than to the ones with DSVS. Obviously vasoconstriction was induced by application of IAB to the basilar arteries with and without DCVS. This fact strongly indicates the IAB is the mani cause of DCVS. Our data suggests that there are some simportant agent in blood causing DCVS besides Hb. This agent seems to have more potent vasoconstriction activity than that of Hb.