支撑导管内加压防治胆肠吻合口狭窄的超微结构研究

Astereologic study on the influence of stent tube pres-sure on bilio-intestinal anastomotic scar formation

胆道损伤后容易形成瘢痕性狭窄，引起梗阻性黄疸和胆汁性肝硬变。为了避免吻合口狭窄的并发症，在吻合口内放置内支撑导管效果较为理想。但支撑管对吻合口瘢痕组织有何影响，作者通过建立几种不同类型的动物模型，分别于术后３周、３个月、６个月、９个月和１２个月取材，对吻合口组织进行超微结构立体学图象分析。从瘢痕形成过程的角度，阐明支撑导管内加压对胆肠吻合口瘢痕形成的影响，明确支撑管放置的时间应不少于９个月。

AbstractBiliary tract injury results often in biliary scarstricture causing obstructive jaundice and biliary cir-rhosis,Choledocho-jejunostorny with tube stent is theroutine to prevent anastomotic stenosis,but how longthe stent tube should be in place is controversial andlittle is known on the influence of the stent tube onandstomotic scar formation,In canine experimentalmodels,bili-intestinal scar was sampled 3 weeks,3,6,9 and 12 months after anastomosis for ultrastructurestereologic image analysis,It was found that the inter-nal pressure of the stent tube exerting on anastomoticstoma inmhts scar formation,and the stent tubeshould be remained inside the stoma for not less than 9months。