转移性肺癌冷冻外科治疗20年回顾

Cryosurgical resection of pulmonary metastases(Expe-rience of Twenty Years)

作者从１９７３年到１９９３年共对ｌ１２例转移性肺癌患者进行了冷冻治疗，总生存率１、３、５、１０年分别为８０．３７％、４１．８１％、２８．０１％和１７．２８％。无瘤间期与术后生存率明显相关，多因素分析也证明无病间期是转移性肺癌冷冻治疗的最重要的影响预后的因素。本组冷冻治疗转移性肺癌５年总生存率较文献报道手术切除肺转移平均生存率高，显示冷冻治疗有一定优越性。本组资料表明，转移性肺癌冷冻治疗安全有效，多数病例可延长生存期。

AbstractCryosurgical resection of pulmonary metastaseswas performed in 112 patients from 1973 to 1993.Thecumulative1,3,5, 10 vear survival rate was 80.37%,41. 81%, 28.01%and 17.28%。One patient died ofrespiratory failure after operation。 Thirty-day mortali-tv rate was 0. 89%。The disease-free interval(DFI)be-tween the control of prinlary tunior and apperance ofmetastases was significantly correlated with post-tho-ractomy survival.The muItiple factor analvsis also de-monstrated that DFl was the most important prognos-tic factor for patients after cryosurgical resection ofpulmonary metastatic lesions。The overall 5 vear sur-vival rate of patients treated with cryosurgery in ourreport was higher than that of those treated by localresection of pulmonary metastases reported by otherauthors。 Our results indicated that cryosurgical resec-tion of pulmonary metastases was effective and safe,the survival time of most patients could be prolongedand some patients could be cured。