^（99m）Tc－MIBI显像用于诊断门静脉高压症的实验研究

￣(99m)Tc-MIBI used for diagnosis of portal hypertension:an experimental study

作者通过实验性肝硬变大鼠心、肝对￣（９９ｍ）Ｔｃ－ＭＩＢＩ（￣（９９ｍ）Ｔｃ－甲氧基异腈）的显像考察了其诊断门静脉高压症的价值。经直肠或结肠中静脉注入￣（９９ｍ）Ｔｃ－ＭＩＢＩ后定时行心、肝区γ－摄像，由此求得心／肝比（Ｎ／Ｌ）和分流指数（ＳＩ）。结果显示，肝硬变鼠的Ｈ／Ｌ。明显高于正常鼠；直肠给药时Ｈ／Ｌ与自由门静脉压力（ＦＰＰ）的相关性较结肠中静脉给药时为好，说明经直肠给药是可靠的。经直肠给药的肝硬变鼠的Ｈ／Ｌ与ＦＰＰ呈正相关（γ＝０．８３，Ｐ＜０．０１），由回归方程ＦＰＰ（ｋＰａ）＝０．２４＋４．０６（Ｈ／Ｌ）推算的肝硬变大鼠的门静脉压力与实测的ＦＰＰ有良好的相关性（γ＝０．８５，ｐ＜０．０１），表明该方法可用于肝硬变时门静脉压力的预测。

AbstractThe authors investigated the relationship betweenportal-systemic shunting and portal pressure in 16CCl_4-induced cirrhotic wistar rats by￣(99m)Tc-NIIBI photography of heart and liver. Based on radio-countstaken at 30 minutes after ￣(99m)Tc-MIBI was given perrectum 8 rats or medial clonic vein 8 rats,heart radio-counts/liver radio-counts( H/L)3ndportal-systemicshunting index(SI) were recorded.It was shown that1.H/L and SI of the two cirrhotic groups were greaterthan those of normals(P<0. 001); 2. H/L in cirrhoticrats by rectum ￣(99m)Tc-MIBI administration was moreclosely related to free portal pressure(FPP,r=0. 83,P<0.01 ) than in those bv venous route(I=0.74,P<0. 05)and its regressive formation FPP(kPa)=0. 24+4.06 (H/L) was deduced and used to calculate portalpressure of cirrhotic rats. The very good relationshipbetween the calculated and measured portal venouspressure was shown in a group of I2 cirrhotic rats(r=0. 85,P<0. 01).These findings suggested that the rec-tum administration of ￣(99m)Tc-MIBI may be a usefulmethod in calculating portal pressure and portal-sys-temic shunting in portal hypertensive patients。