烧伤休克延迟补液对肝、肾的影响

The injury of liver and kidney of rats sustaining de-byded fluid resuscitation of burn shock

烧伤休克延迟补液会对机体造成进一步损伤。作者研究了烧伤大鼠在不补液、立即补液和延迟补液三种复苏条件下的肝、肾损伤情况。结果显示，烧伤早期肝、肾中可产生多量的超氧阴离子并发生脂质过氧化反应，对脏器造成不同程度的损伤，延迟补液组和不补液组损伤更为明显。实验提示，立即补液对肝、肾仅有部分保护作用，严重烧伤早期的液体复苏应辅以氧自由基清除剂。

AbstractDelayed fluid resuscitation of burn shock may leadto many harmful effects;We investigated the injury ofliver and kidney of rats sustaining non-fluid perfusion,immediate perfusion, and delayed perfusion of burnshock.The electron spin remonance(ESR)was used todetermine the existence of oxygen free radicals(OFR)successfully. We tested the activity of ATP enzyme inkidney,lactate dehydrogenase isoenzyme 5(LDH_5),GPT and GOT. We also tested the contents of malonaldehyde(MDA) and ATP in liver and kidney, urea ni-trogen(BUN and creatinine(Cr) in blood.We foundthat OFR plays an important role in the injury of liverand kidney sustaining delayed fluid resuscitation ofburn shock. Immediate fluid perfusion can not protectthe liver and kidney perfectly,And some OFR scav-engers should be added to the fluid resuscitaion of burnshock.