血小板活化因子及其受体拮抗剂对脊髓损伤后脊髓血流量的影响

Effects of platelet activating factor and platelet activat-ing factor receptor antagonist on spinal cord blood flowafter spinal cord injury

实验采用鞘内注射血小板活化因子（ＰＡＦ）及静脉注射ＰＡＦ受体桔抗剂ＢＮ＿（５２０２１），观察其对猫脊髓损伤后伤区和邻近脊髓（Ｌ＿２～Ｌ＿４）血流量及血浆血栓素Ｂ＿２（ＴＸＢ＿２）、６－酮－前列腺素１α（６－ｋｅｔｏ－ｐＧＦ＿（１α））比值（Ｔ／Ｋ值）的影响。结果显示，ＰＡＦ组Ｌ＿２～Ｌ＿４节段灰、白质血流量较单纯脊髓损伤组下降更为明显，Ｔ／Ｋ值明显升高。而ＢＮ＿（５２０２１）组Ｌ＿２～Ｌ＿４节段灰、白质血流量较单纯脊髓损伤组明显增加，Ｔ／Ｋ值显著降低。结果表明，ＰＡＦ是导致脊髓损伤后血流量减少的重要因子，ＰＡＦ受体桔抗剂ＢＮ＿（５２０２１）能明显改善脊髓损伤后脊髓血流量，减轻伤后继发性损害。

AbstractPlatelet activating factor (PAF) and PAF receptorantagonist BN_(52021) were respectively administered by in-trathecal or intravenous injection in cats. We observedtheir effects on blood flow and TXB_2/6-keto-pGF_(1α)ra-tio (T/ K ratio)in injured spinal cord and its adjacentregion(L_2～L_4)s after trauma. The results showed thatgray matter and white matter blood flow at L_2～L_4 segment significantly decreased T/K ratio elevated ev-idently in PAF group as compared with simple spinalcord injury group, while gray matter and white matterblood flow at L_2～L_4 segment significantly increased andT/K ratio markedly decreased in BN_(52021) group as com-pared with simple spinal cord injury group; The resultsdemonstrate and that PAF is an important factor lead-ing to spinal cord blood flow reduction after trauma,and that PAF receptor antagonist BN_(52021) can evidentlyimprove spinal cord blood flow and relieve secondarydamage after trauma.