前列腺素E_1对C－BSA原位肾炎血清白细胞介素1、肿瘤坏死因子及病理变化的调节

PROSTAGLANDIN E INHIBITS INTERLEUKINl,TUMOR NECROSls FACTOR AND AMELIO-RATES INJURY IN AN EXPERIMENTAL MODELOF IN SITU GLOMERULONEPHRITIS

探讨了炎性细胞因子白细胞介素１（ＩＬ－１）和肿瘤坏死因子（ＴＮＦ）在大鼠Ｃ－ＢＳＡ肾炎中的变化及加用外源性前列腺素Ｅ＿１（ＰＧＥ＿１）对这些因子的调节作用。结果表明：Ｃ－ＢＳＡ肾炎模型血清ＩＬ－１和ＴＮＦ均较对照明显升高。加用ＰＧＥ＿１则明显抑制ＩＬ－１和ＴＮＦ活性水平并改善血栓素一前列环素平衡，同时２４小时尿蛋白定量显著下降，肾脏病理变化减轻。结果提示：ＩＬ－１、ＴＮＦ在肾炎发病机理中可能起了重要作用，外源性ＰＧＥ＿１可以抑制其产生和释放并缓解病情发展。

his study have researched the role of tumornecrosis factor (TNF), interleukin 1 (IL) in experimen-tal C-BSA glomerulonephritis in rats and the effect ofadministration of extragenous prostaglandin E, (PGE,)on these cytokines- As result,the sera level of IL,TNFin C - BSA model group have significantly in-creased. Howere,the bioactivities of iL, and TNF havebeen inhibited significantly while protenuria and patho-logical injuries have been improved in PGE , therapeuticgroup. These results suggest that cytokines (IL,TNF)may play a important role in the pathogenesis of glom-erulonephritis and extragenous PGE, can suppressthess cytokines and ameliorates pathological injuries inrats C-BSA glomerulonephritis.