可溶性白细胞介素2受体在轮状病毒胃肠炎中价值的初探

A Preliminary Study on the Evaluation of Soluble Interleukin-2 Receptor (SIL-2R) in Rotavirus Gastroenteritis

动态观察轮状病毒胃肠炎患儿血浆中可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）水平的变化，以及轮状病毒（ＲＶ）浓度与ＳＩＬ－２Ｒ，ＩＬ－２与ＳＩＬ－２Ｒ水平之间的关系。结果显示：急性期患儿血浆中ＳＩＬ－２Ｒ明显升高（５１６６００±１４５０００Ｕ／Ｌ），Ｐ＜０．００１），恢复期患儿血浆中ＳＩＬ－２Ｒ接近正常（３５４．２９０±１２２０００Ｕ／Ｌ，Ｐ＞０．０５）；在ＲＶ抗原诱导下末梢血中单个核细胞可释放ＳＩＬ－２Ｒ；ＲＶ浓度与ＳＩＬ－２Ｒ水平呈负相关（ｒ＝－０．７０１９，Ｐ＜０．０５），ＩＬ－２水平与ＳＩＬ－２Ｒ亦呈负相关（ｒ＝－０．６６１１，Ｐ＜０．０１）。提示：ＳＩＬ－２Ｒ分泌增高可能是ＲＶ激活免疫细胞后的结果，可间接反映ＩＬ－２水平且与病情转归密切有关，是一种简易、快速、敏感的细胞免疫新指标。

We have dynamiclly observed the changes of SIL-2R serun of children with rotavirus gastroenteritis. Studies were also performed on the relation between rotavirus (RV) concentration and SIL-2R level and between levels of interleukin-2 (IL-2) and SIL-2R. The results showed that the level was significantly increased in acute stage (516.60±146 000U/L,P<0.001)and gradually decreased to normal in the recovery stage (354.29±122U/L); SIL-2R might be released by peripheral blood mononuclear cell while induced by RV; SIL-2 levels was negative correlated with RV concentration (r=-0.7019,P<0.05) and negatively correlated with IL-2 level (r=-0.6611,P<0.01). These data suggest that SIL-2R may be the product of immune cell activated by RV, it may indirectly reflect the level of IL-2 and affect the prognosis of the disease. We would like to conclude that SIL-2R is a simple,rapid and sensible new indicator of cell mediated immunity.