摘要
对乙型肝炎肝硬化(HBC)尸检12例肾脏病理与免疫病理进行观察,免疫病理发现在肾小球的内膜和系膜区有乙型肝炎病毒抗体IgM、IgA、IgG和免疫复合物C3、Clq沉积,只发现1例有HBSAg阳性(8.3%)。提示可能肾脏损害与HBV直接作用的关系不大,而作为抗原引起体液免疫或通过循环免疫复合物沉积与肾病变关系较密切。
A Study on renal pathology and immunopathology in 12 autopsied cases of hepatitis B virus (HBV) infectious cirrhosis was performed. It was found that antibodies of anti-HBV IgM,IgA, IgG and complement.C3,Clq deposited in endothelium and mesentery of glomerulus.only one patient was positive in hepatitis B surface antigen (HBsAg) and hepatitis B core anligen (HBcAg) Was negative in all 12 patients, as examined by immunopathological detection. These results suggest there was no significant correlation between renal damages and direct effect of HBV, and the humonal immune reaction induced by HBV antigens or the deposit product of circulatory immune complex may play a significant role in the development of renal immuno pathology.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1995年第3期221-223,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
乙型肝炎
肝硬变
肾损害
病理
Hepatitis virus, Cirrhosis, Renal diseases, Immunopathology, Immune complex