胃癌大肠癌病人红细胞免疫功能的变化

Changes of the red cell immune function with carcinoma of stomach and carcinoma of large intestine

观察25例胃癌和15例大肠癌病人手术前后一周内红细胞C_(3b)受体花环试验(RBC-C_(3b)和红细胞免疫复合物花环率试验。结果显示,胃癌大肠癌病人红细胞C_(3b)受体免疫粘附功能显著低于正常对照组,部分胃癌病人红细胞免疫复合物花环率显著低于正常人,部分胃癌病人变化不明显。手术和化疗不影响红细胞免疫功能。提示红细胞免疫功能缺陷可能是原发或继发,红细胞C_(3b)受体损坏可能是不可逆的,动态观察红细胞免疫功能有重要的临床意义。

The authors observed dynamically the changes of the red cell c3b receptor rosette test (RBC-c3b) and the red cell immune complexes rosette test (RBC-IC) in 25patients with gastric cancer and 15 patients with Large intestinal cancer (colon or rectal cancer), within 1 week of pre- and post- operation. The results revealed that the red cell c3b receptor immune adherence function in gastric cancer and large intestinal cancer is significantly lower than normal people. The red cell immune complexes rosette rate of part of gastric cancer patients is significantly lower than normal people,it don't remarkedly changes in other patients. Operation and Chemical therapy do not influence the red cell immune function. The results indicated that the defect of the red cell Immune function is probably primary or secondary, that the injury of the red cell c3b receptor is possible ir-reversable, there is important clinical significance to dynamically observe the red cell immune function.