胃癌雌激素受体、癌胚抗原和DNA含量及其预后关系的研究

Estrogen receptor,carcinoembronic anti-gen,DNA content and their relation with gastric cancer.

用ＡＢＣ免疫组化技术测定６５例胃癌标本中ＥＲ、ＣＥＡ含量，其中３６例标本行ＤＮＡ图像分析测定，并对影响胃癌预后的２７种因子进行Ｃｏｘ模型分析。结果发现胃癌ＥＲ、ＣＥＡ阳性率与浸润深度、淋巴结转移正相关，与分化程度负相关，ＥＲ、ＣＥＡ阴性胃癌预后较好，ＥＲ阳性胃癌对化疗较敏感。二倍体胃癌预后优于异倍体胃癌，晚期、分化差胃癌细胞核ＤＮＡ含量高。影响胃癌预后的六种因子依次为：病理类型、病程、ＤＮＡ含量、化疗、淋巴结转移和ＥＲ含量。

Etrogen recepto(ER)and carcinoembry-onic antigen(CEA)were measured in 65 pa-tients with gastric cancer by Avidin-biotinperoxidase complex(ABC)immunonis-tochemical technique and the image cytometric(ICM)DNA analysis technique was used tomeasure the muclear DNA content in 36 of the65 patients,27 parameters which might be rel-ative with prognosis were analyzed by Cox re-gression model.The results showed that ERand CEA positive rate were positively corre-lated with the invasive depth,the extent oflymph node metastasis and inversely with thedegree of differentiation.The patients withER-or CEA-positive gastric cancer was moresensitive to chemotherapy than ER-negativeone.The patients with diploid gastric cancerhad much better prognosis than those with a-neuploid gastric caner.The gastric cancerwhich have poorer differentiation or in lateclinicpathological stages had much great cellu-lar DNA content.6 prognostic parameters ofgastric cancer were histopathological types,courses of disease,DNA content,chemothera-py,lymph node metastasis and ER content.The results suggested ER and DNA content ofgastric ncer correlates with its prognosis.